Endocrine Abstracts

Objective: Polycystic ovary syndrome (PCOS) is characterized by biochemical and clinical androgen excess and disturbed ovarian function and is associated with disorders of glucose and lipid metabolism. Isoflavones are phytoestrogens exerting endocrine effects on human hormone and metabolic signaling and may influence symptom penetrance in PCOS. We investigated whether women with PCOS and healthy controls have alterations in their capacity to metabolize hormonally active dietar...

Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting 10-15% of women worldwide, characterized by high androgen levels, anovulation and/or polycystic ovarian morphology. Chronic low-grade inflammation is associated with the disorder as well as many of its comorbidities, such as obesity and type-2 diabetes. To determine the role of the immune system in the pathophysiology of PCOS, we characterized the immune profile of the dihydrotestosterone (DHT)-induced PCOS-li...

Background: Age-associated double negative (DN) B memory cells lacking surface expression of CD27 and IgD have been associated with proinflammatory characteristics, higher disease activity in autoimmune diseases and disease-specific autoantibodies. We studied the distribution of DN B cells in Polycystic Ovary Syndrome (PCOS), their surface markers and cytokine production.Methods: CD19+ cell subpopulations on the basis of IgD and CD27 expression were phen...

Objective: Polycystic ovary syndrome (PCOS) affects 5–20% of women of reproductive age worldwide and is associated with disorders of glucose metabolism. Hormone and metabolic signalling may be influenced by phytoestrogens, such as isoflavones. Their endocrine effects may modify symptom penetrance in PCOS.We investigated, whether women with PCOS and healthy controls differ in their capacity to metabolize dietary isoflavones and whether this capacity...

Objective: Age-associated double negative (DN) B memory cells lacking surface expression of CD27 and immunoglobulin D (IgD) are associated with proinflammatory characteristics and higher disease activity in autoimmune diseases. We first characterized B cells phenotypes in women with and without polycystic ovary syndrome (PCOS). We then took an in vivo approach, transferring purified IgG extracted from serum of hyperandrogenic women with PCOS to mice to establish wheth...

Introduction: The hyperandrogenic in utero environment in pregnant women with polycystic ovary syndrome (PCOS) can affect embryo development and impair offspring health at adult age. Moreover, long term hyperandrogenic exposure also leads to unfavored changes to the mothers’ reproductive physiology, leading to miscarriage, preterm delivery, and perinatal mortality. The underlying mechanism(s) of pregnancy complications associated with PCOS and the consequence of ...